Tuberous sclerosis complex (TSC) is a genetic disorder that
causes tumors to form in many different organs, primarily in the brain, eyes,
heart, kidney, skin and lungs. You will see it referred to both as tuberous
sclerosis (TS) and tuberous sclerosis complex (TSC).
The true prevalence of TSC is unknown, but its incidence has
recently been estimated to be 1 in 6,000 live births. This means approximately
50,000 individuals in the
United
States and more than 1 million worldwide have TSC. It occurs in both sexes and
in all races and ethnic groups.
Because TSC is a genetic disorder, it is not contagious. It is the result of
a genetic mutation over which a parent has no control. It is often first
recognized in children who have two neurological symptoms—epileptic seizures
and/or varying degrees of mental handicap. However, the clinical symptoms of TSC
vary greatly and may often not appear until later in life. There are presently
no cures and there is no way to predict how severely or mildly an individual may
be affected by